Covid pfizer second dose timing9/15/2023 ![]() ![]() ![]() Theoretically, combining doses from different manufacturers should still trigger an effective immune response, since almost all of the Covid-19 vaccines being developed are based on the same viral ‘“spike” protein, even if this is presented to our bodies in slightly different ways.Ĭould other countries follow the UK? Possibly. ![]() What about mixing and matching doses from different manufacturers? This also hasn’t been tested in clinical trials – although UK and Russian scientists are investigating whether combining shots of the Oxford/AstraZeneca and Sputnik V vaccines could result in better protection than two doses of the same one. However, a consensus statement by the British Society for Immunologists said that delaying the booster dose by eight or nine weeks was unlikely make much difference in thee longer-term. Pfizer cautioned that its trial only investigated giving two doses 21 days apart – far less than 12 weeks. The main risk is that people’s level of immunity falls before they receive their second dose, putting them at risk of Covid-19 – although this risk would still be lower than if they’d received no vaccine, and would be boosted when they eventually received their second shot. Neither has giving a first dose of the Pfizer/BioNTech vaccine, followed by a second dose of the Oxford/AstraZeneca vaccine, or vice versa – which the JCVI advises only in “exceptional circumstances”, eg if a second dose of the original vaccine isn’t available. ![]() People aged 12 years and up who previously received one or more doses of Novavax COVID-19 vaccine are recommended to receive one bivalent mRNA vaccine dose at least 8 weeks after their last monovalent dose.Why are some scientists concerned about it? Chiefly because the impact of stretching out the two doses hasn’t been tested in clinical trials.An 8-week interval between the first and second primary series doses might be optimal for some people ages 6 months–64 years, especially for males 12–39 years old. The second of the two doses should be administered 3-8 weeks after the first dose. Novavax can be used as a two-dose primary series for individuals 12+ years old.** The monovalent Novavax COVID-19 vaccine remains authorized for the following scenarios: Minimum 2-month (60-day) interval after bivalent dose 1 ( optional)Īt least 2 months after bivalent dose 2 ( optional)Ģ doses monovalent Moderna, with no bivalent dosesģ doses monovalent Moderna, with no bivalent dosesģ doses monovalent Pfizer-BioNTech, with no bivalent dosesĮver received at least 1 dose bivalent Moderna or Pfizer-BioNTechģ doses monovalent Moderna or 3 doses monovalent Pfizer-BioNTech, with no bivalent dosesĪt least 3 doses of monovalent Moderna or Pfizer-BioNTech, with no bivalent doses Minimum 2-month (60-day) interval after bivalent dose 2 ( optional) (21-day) interval after last monovalent doseĢ doses monovalent Pfizer-BioNTech, with no bivalent dosesģ doses of Pfizer-BioNTech, with no bivalent dosesĮver received at least 1 bivalent dose of Moderna or Pfizer-BioNTech (56-day) interval after last monovalent doseġ dose monovalent Pfizer-BioNTech, with no bivalent doses Minimum 2-month (60-day) interval ( optional)ģ doses of monovalent Moderna, with no bivalent doses Minimum 2-month (60-day) interval ( optional)*Ģ or more doses monovalent Moderna, with no bivalent doses (28-day) interval after last monovalent dose Where possible, the additional dose(s) should be homologous (should match) with previous doses given.ĭosing Schedule: Immunocompromised, Any History of COVID-19 Vaccinationġ dose monovalent Moderna, with no bivalent doses Any further doses should be administered at least 2 months following the most recent COVID-19 vaccine dose. * For moderately to severely immunocompromised individuals, further additional dose(s) may be administered based on clinical judgment of a health care provider and personal preference/circumstances. Are unable or unwilling to receive an mRNA vaccine and would not otherwise receive a booster dose.ĭosing Schedule: Immunocompromised, No History of COVID-19 Vaccination ![]()
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